I love this picture Ron Garan uploaded from the space station today. The moon looks so tiny! I think it's interesting that when viewed from the earth the moon against the horizon looks bigger from brain fail basically, but this picture with another object in the frame makes it look so small.
Phil Plait had a post recently about the moon being squished by atmospheric effects. That's nothing to do with this specifically, but if you click the link and look at those pictures of the moon you'll see Paulo Nespoli shot them with a longer lens. He was zoomed in on the moon. This is more like a wide angle lens to get the whole shuttle in the picture. That will make the moon seem farther away/smaller, like the side rear view mirror on your car versus the middle one.